Napoli striker, Victor Osimhen, bagged a brace in their 4-0 win over Sampdoria on Thursday.
The victory saw them maintain their perfect start to the Serie A season and return to the top of the table.
However, they rode their luck in the opening 35 minutes in Genoa.
Napoli took control after 39 minutes when Fabian Ruiz passed the ball into the corner of Audero’s goal from 20 metres.
Osimhen added a second after 50 minutes, running onto Hirving Lozano’s low cross from the right and drilling the ball home from the edge of the six-yard box.
Piot Zielinski added a carbon copy goal nine minutes later as he met a low Lozano pullback with a crisp shot.
The victory took Napoli back to the top of the table with 15 points from their first five league games under Luciano Spalletti.
They moved two ahead of champions Inter Milan, who won 3-1 at Fiorentina on Tuesday, and AC Milan, who beat Venezia on Wednesday.