Super Eagles striker, Victor Osimhen, scored the only goal as Napolo defeated Torino 1-0 on Sunday.
The win saw them return to the top of Serie A.
AC Milan had taken first spot, after battling back from two goals down to beat Hellas Verona 3-2 at the San Siro on Saturday.
But Napoli moved back to the summit after Osimhen, who had scored for his country in a 2-0 win against the Central African Republic in World Cup qualifying last week, headed the 81st-minute winner.
Napoli have 24 points, two more than AC Milan while reigning champions Inter Milan are on 17 points after losing ground following a 3-1 defeat away to Lazio on Saturday.
Atalanta were easy 4-1 winners against Empoli on Sunday as they warmed up to take on Manchester United at Old Trafford in the Champions League on Wednesday.