Manchester United will play Aston Villa in the FA Cup third round.
Liverpool will welcome Shrewsbury Town, while Arsenal travel to Nottingham Forest.
Chelsea, last year’s losing finalists, play non-league Chesterfield.
Pep Guardiola, who has only won the FA Cup once, will prepare Manchester City for a trip to Swindon Town.
The games will be played the weekend of January 8, 2022.
Boreham Wood/St Albans vs AFC Wimbledon
Yeovil Town vs Bournemouth
Stoke City vs Leyton Orient
Swansea City vs Southampton
Chelsea vs Chesterfield
Liverpool vs Shrewsbury Town
Cardiff City vs Preston North End
Coventry City vs Derby County
Burnley vs Huddersfield Town
West Bromwich Albion vs Brighton and Hove Albion
Kidderminster Harriers vs Reading
Leicester City vs Watford
Mansfield Town vs Middlesbrough
Hartlepool United vs Blackpool
Hull City vs Everton
Bristol City vs Fulham
Tottenham Hotspur vs Morecambe
Millwall vs Crystal Palace
Port Vale vs Brentford
Swindon Town vs Manchester City
Wigan Athletic vs Blackburn Rovers
Luton Town vs Harrogate Town
Birmingham City vs Plymouth Argyle
Manchester United vs Aston Villa
Wolverhampton Wanderers vs Sheffield United
Newcastle United vs Cambridge United
Barnsley vs Ipswich Town/Barrow
Peterborough United vs Bristol Rovers
West Ham United vs Leeds United
QPR vs Rotherham United
Charlton Athletic vs Norwich City
Nottingham Forest vs Arsenal